Neurobiology of the Vertebrate Retina Lab



 Principal Investigator:

  Dra. María Paula Faillace, Ph.D. in Biological Sciences.
  Research Investigator, CONICET
  Department of Physiology, School of Medicine, University of Buenos Aires (UBA).

  Ph.D. Students:

  Ricatti, María Jimena Physician/full time Teaching Assistant, UBA)
  Battista, Ariadna Gabriela (Graduate Student in Biological Sciences, ANPCYT fellowship)

  Undergraduate Student Thesis:

  Gautier, Marien Amanda (Undergraduate Student in Biological Sciences, School of Sciences, UBA).




  Undergraduate Student Thesis (Past):

  Lionel David Alfie (Graduate Student in Biological Sciences, School of Sciences, UBA). Qualification: Outstanding.
  Mercedes Pérez Recalde (Graduate Student in Biological Sciences, School of Sciences, UBA. Qualification: Outstanding.
  Co-advised with Dr. Pablo Schwarzbaum.

  Undergraduate Student Collaborators:

  Diego Villagra Satto (School of Medicine, UBA).

  Collaborations:

  Dr. Pablo Schwarzbaum
  Dr. Ramón Oscar Bernabeu


Research Lines in the Lab

Publications: Pubmed link (search as Faillace mp):
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=faillace+mp&log$=activity


Research Topic Abstract

Our Lab study neurogenesis and differentiation in the adult zebrafish retina. We use the zebrafish retina as a model because it offers unique features to investigate extracellular (extrinsic) as well as genetic (intrinsic) factors that regulate neuronal and glial differentiation in a tissue of the adult nervous system. We examine extrinsic signals effect on the expression of transcription factors in differentiating retinal cells. Furthermore, we analyze the effect of extracellular signals, such as purinergic or glutamatergic systems, on the morphological differentiation of progenitor cells. We also study the role of such signals on regeneration after damaging the retina. We aim to contribute with valuable knowledge that could be useful for treating degenerative diseases that involve lost of several retinal cell types and cause blindness in humans. Our Lab study neurogenesis and differentiation in the adult zebrafish retina. We use the zebrafish retina as a model because it offers unique features to investigate extracellular (extrinsic) as well as genetic (intrinsic) factors that regulate neuronal and glial differentiation in a tissue of the adult nervous system. We examine extrinsic signals effect on the expression of transcription factors in differentiating retinal cells. Furthermore, we analyze the effect of extracellular signals, such as purinergic or glutamatergic systems, on the morphological differentiation of progenitor cells. We also study the role of such signals on regeneration after damaging the retina. We aim to contribute with valuable knowledge that could be useful for treating degenerative diseases that involve lost of several retinal cell types and cause blindness in humans.





            

Lab Contact:
Laboratorio de Neurociencias - Departamento de Fisiología - Facultad de Medicina - UBA.
Paraguay 2155 (1121) Buenos Aires - Argentina
phone / fax: 54 11 5950-9611
phone: 54 11 5950-9500 extension 2148
email:laboneurociencias@gmail.com