INBIOMED

Publicaciones

​​​​​Publicaciones y Reconocimientos:

2019

  • J. Saba, L. Carniglia, D. Ramírez, J. Turati, M. Imsen, D. Durand, M. Lasaga, C. Caruso. “Melanocortin 4 receptor activation protects striatal neurons and glial cells from 3-nitropropionic acid toxicity” Mol Cell Neurosci 2019, 94:41-51. doi 10.1016/j.mcn.2018.12.00.
     
  • D. Ramírez, J. Saba, J. Turati, L. Carniglia, D. Durand, C. Caruso, M. Lasaga. “NDP-MSH reduces oxidative damage induced by palmitic acid in primary astrocytes” J Neuroendocrinol 2019 Feb 3:e12673. doi: 10.1111/jne.12673.
     
  • D. Durand, Turati, M.J. Rudi, D. Ramírez, L. Carniglia, J. Saba, C. Caruso, von Bernhardi R., M. Lasaga “Unraveling the b–amyloid clearance by astrocytes: Involvement of metabotropic glutamate receptor 3, sAPPa, and class-A scavenger receptor”. Neurochem Int. 2019 131:104547. doi: 10.1016/j.neuint.2019.104547
     
  • Sciurano RB, Pigozzi MI, Benavente R. Disassembly of the synaptonemal complex in chicken oocytes analyzed by super-resolution microscopy. Chromosoma. doi:10.1007/s00412-019-00693-w. PubMed PMID: 30793238

  • Angiotensin II stimulation promotes mitochondrial fusion as a novel mechanism involved in protein kinase compartmentalization and cholesterol transport in human adrenocortical cells. Katia E. Helfenberger, Ana F. Castillo, Pablo G. Mele, Ana Fiore, Lucía Herrera, Paola Finocchietto, Ernesto J. Podestá; Cecilia Poderoso. J Steroid Biochem Mol Biol. Jun 13 (2019);192:105413. doi: 10.1016/j.jsbmb.2019.105413. 

  • The effect of Nitric Oxide on mitochondrial respiration. Juan José Poderoso, Katia E. Helfenberger, Cecilia Poderoso. Nitric Oxide. Jul 1 (2019); 88: 61-72. doi: 10.1016/j.niox.2019.04.005.

  • “Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord”. Diego Moreno, Cristian M Sobarzo, Livia Lustig, Marcelo G Rodríguez Peña, Vanesa Anabella Guazzone. Asian Journal of Andrology. doi: 10.4103/aja.aja_30_19. 2019

  • “Autoimmune orchitis and autoimmune oophoritis”. L. Lustig, V.A.Guazzone, K.S.K. Tung. Capítulo del libro: “The Autoimmune Diseases”. 6a. edición. N. Rose and I. R. Mackay, eds. Elsevier/Academic Press, en prensa, 2019. isbn 978-0-12-384929-8

  • Camilletti MA, Abeledo Machado AI, Pérez PA, Faraoni EY, De Fino F, Rulli SB, Ferraris J, Pisera D, Gutiérrez S, Thomas P, Diaz-Torga G. mPRs represent a novel target for PRL inhibition in experimental prolactinomas. Endocr Relat Cancer. 2019 Mar 1. pii: ERC-18-0409.R2. doi: 10.1530/ERC-18-0409. [Epub ahead of print]

  • de Dios N, Orrillo SJ, Irizarri M, Theas M, Boutillon F, Candolfi M, Seilicovich A, Goffin V, Pisera D, Ferraris J. JAK2/STAT5 pathway mediates prolactin-induced apoptosis of lactotropes. Neuroendocrinology. 2019;108(2):84-97. doi: 10.1159/000494975.

  • Camilletti MA, Abeledo Machado AI, Ferraris J, Pérez PA, Faraoni EY, Pisera D, Gutiérrez S, Diaz-Torga G. Role of GPER in the anterior pituitary gland focusing on lactotroph function. J Endocrinol. 2019 Feb 1;240(2):99-110. doi: 10.1530/JOE-18-0402.

2018

  • Camilletti MA, Ferraris J, Abeledo-Machado A, Converse A, Faraoni E, Pisera D, Gutierrez S, Thomas P, Díaz-Torga G. Participation of membrane progesterone receptor α in the inhibitory effect of progesterone on prolactin secretion. . J Neuroendocrinol. 2018 Sep;30(9):e12614. doi: 10.1111/jne.12614.

  • "Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4". Carvajal G, Brukman NG, Weigel Muñoz M, Battistone MA, Guazzone VA, Ikawa M, Haruhiko M, Lustig L, Breton S, Cuasnicu PS. Sci Rep. 8(1): 17531. doi: 10.1038/s41598-018-35719-3. 2018.

  • Guest Editors Foreword. Livia. Lustig, Jean-.Pierre Allam. Suppl. ANDROLOGIA “Current concepts in inflammatory disorders in male infertility”, V50 (issue 11) doi: 10.1111/and.13186 , 2018.

  • Nielsen SM et al. Genetic Testing and Clinical Management Practices for Variants in Non-BRCA1/2 Breast (and Breast and Ovarian) Cancer Susceptibility Genes: an International Survey by the ENIGMA Clinical Working Group,"  Journal of Clinical Oncology Precision Oncology, in press, 2018.  Coautora Solano AR.

  • From colorectal cancer pattern to the characterization of individuals at risk: picture for genetic research in Latin America, Mini Review in "Cancer Genetics and Epigenetics" of the International Journal of Cancer, in press, 2018. Coautora Solano AR.

  • Acyl-CoA Synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression. Ulises D Orlando, Ph.D; Ana F Castillo, Ph.D; Mayra A Ríos Medrano, Technician; Angela R Solano, Ph.D; Paula M Maloberti, Ph.D; Ernesto J Podestá, Prof. Ph.D. Biochemical Pharmacology 2018. in press.

  • Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations. Rebbeck TR, Friebel TM, Friedman E, Hamann U, Huo D, Kwong A, Olah E, Olopade OI, Solano AR, Teo SH, Thomassen M, Weitzel JN, Chan TL, Couch FJ, Goldgar DE, Kruse TA, Palmero EI, Park SK, Torres D, van Rensburg EJ, McGuffog L, Parsons MT, Leslie G, Aalfs CM, Abugattas J, Adlard J, Agata S, Aittomäki K, Andrews L, Andrulis IL, Arason A, Arnold N, Arun BK, Asseryanis E, Auerbach L, Azzollini J, Balmaña J, Barile M, Barkardottir RB, Barrowdale D, Benitez J, Berger A, Berger R, Blanco AM, Blazer KR, Blok MJ, Bonadona V, Bonanni B, Bradbury AR, Brewer C, Buecher B, Buys SS, Caldes T, Caliebe A, Caligo MA, Campbell I, Caputo SM, Chiquette J, Chung WK, Claes KBM, Collée JM, Cook J, Davidson R, de la Hoya M, De Leeneer K, de Pauw A, Delnatte C, Diez O, Ding YC, Ditsch N, Domchek SM, Dorfling CM, Velazquez C, Dworniczak B, Eason J, Easton DF, Eeles R, Ehrencrona H, Ejlertsen B; EMBRACE, Engel C, Engert S, Evans DG, Faivre L, Feliubadaló L, Ferrer SF, Foretova L, Fowler J, Frost D, Galvão HCR, Ganz PA, Garber J, Gauthier-Villars M, Gehrig A; GEMO Study Collaborators, Gerdes AM, Gesta P, Giannini G, Giraud S, Glendon G, Godwin AK, Greene MH, Gronwald J, Gutierrez-Barrera A, Hahnen E, Hauke J; HEBON, Henderson A, Hentschel J, Hogervorst FBL, Honisch E, Imyanitov EN, Isaacs C, Izatt L, Izquierdo A, Jakubowska A, James P, Janavicius R, Jensen UB, John EM, Vijai J, Kaczmarek K, Karlan BY, Kast K, Investigators K, Kim SW, Konstantopoulou I, Korach J, Laitman Y, Lasa A, Lasset C, Lázaro C, Lee A, Lee MH, Lester J, Lesueur F, Liljegren A, Lindor NM, Longy M, Loud JT, Lu KH, Lubinski J, Machackova E, Manoukian S, Mari V, Martínez-Bouzas C, Matrai Z, Mebirouk N, Meijers-Heijboer HEJ, Meindl A, Mensenkamp AR, Mickys U, Miller A, Montagna M, Moysich KB, Mulligan AM, Musinsky J, Neuhausen SL, Nevanlinna H, Ngeow J, Nguyen HP, Niederacher D, Nielsen HR, Nielsen FC, Nussbaum RL, Offit K, Öfverholm A, Ong KR, Osorio A, Papi L, Papp J, Pasini B, Pedersen IS, Peixoto A, Peruga N, Peterlongo P, Pohl E, Pradhan N, Prajzendanc K, Prieur F, Pujol P, Radice P, Ramus SJ, Rantala J, Rashid MU, Rhiem K, Robson M, Rodriguez GC, Rogers MT, Rudaitis V, Schmidt AY, Schmutzler RK, Senter L, Shah PD, Sharma P, Side LE, Simard J, Singer CF, Skytte AB, Slavin TP, Snape K, Sobol H, Southey M, Steele L, Steinemann D, Sukiennicki G, Sutter C, Szabo CI, Tan YY, Teixeira MR, Terry MB, Teulé A, Thomas A, Thull DL, Tischkowitz M, Tognazzo S, Toland AE, Topka S, Trainer AH, Tung N, van Asperen CJ, van der Hout AH, van der Kolk LE, van der Luijt RB, Van Heetvelde M, Varesco L, Varon-Mateeva R, Vega A, Villarreal-Garza C, von Wachenfeldt A, Walker L, Wang-Gohrke S, Wappenschmidt B, Weber BHF, Yannoukakos D, Yoon SY, Zanzottera C, Zidan J, Zorn KK, Hutten Selkirk CG, Hulick PJ, Chenevix-Trench G, Spurdle AB, Antoniou AC, Nathanson KL. Hum Mutat. 2018 May;39(5):593-620. doi: 10.1002/humu.23406. Epub 2018 Mar 12.

  • BRCA1 and BRCA2 mutation other than the founder alleles amount Ashkenazi Jewish in the population of Argentina. Angela R Solano, Natalia C Lirial, Fernanda S Jalil, Daniela M Faggionato, Pablo G Mele, Alejandra ,Mampel, Florencia Cardosoand, Ernesto J Podesta. Frontiers in Oncology, August 21th, 2018.

  • ​​​​​BRCA1 and BRCA2 mutations and clinical interpretation in 398 ovarian cancer patients: comparison with breast cancer variants in a similar population. Cardoso FC, Goncalves S, Mele PG, Liria NC, Sganga L, DiazPerez I, Podesta EJ, Solano AR. HumGenomics. 2018 Aug 13;12(1):39. doi: 10.1186/s40246-018-0171-5.
     
  • Inflammation and spermatogenesis. M. S. Theas, P. Jacobo, Pérez C.,V. A. Guazzone, L. Lustig. “Spermatogenesis: Biological and Clinical Implications”. Editado por C. Yan Cheng. CRC Press Editorial. Taylor & Francis Group. 2018.
     
  • C. Caruso.HD 2018 1er premio Investigación sobre Enfermedad de Huntington en Argentina- Fundación HD Lorena Scarafiocca. En búsqueda de nuevos blancos terapeuticos para la enfermedad de Huntington.
     
  • J. Saba, J. Turati, D. Ramírez, L. Carniglia, D. Durand, M. Lasaga, C. Caruso. “Astrocytes truncated-TrkB mediates BDNF antiapoptotic effect leading to neuroprotection”. J Neurochem 2018, doi 10.1111/jnc.14476.
     
  • Kamran N, Alghamri MS, Nunez FJ, Shah D, Asad AS, Candolfi M, Altshuler D, Lowenstein PR, Castro MG.  Current state and future prospects of immunotherapy for glioma. Immunotherapy 2018 10:317-339.
     
  • Gottardo MF, Pidre ML, Zuccato C, Asad AS, Imsen M, Jaita G, Candolfi M, Romanowski V, Seilicovich A. Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors. Apoptosis 2018 23: 143-151. doi: 10.1007/s10495-018-1444-0.
     
  • Guazzone V. A.. Exploring the Role of Antigen presenting cells in Male Genital Tract. Andrologia.: Wiley Online Library. 2018 vol. n°. p - . . eissn 1439-0272
     
  • Surkin PN, Brenhouse H, Deak T, Liberman AC, Lasaga M.Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.J Neuroendocrinol. 2018 Apr 22:e1260 doi: 10.1111/jne.12602. [Epub ahead of print] Review
     
  • Deficiency of Fibroblast Growth Factor 2 (FGF-2) leads to abnormal spermato- genesis and altered  sperm physiology.  Saucedo L,   Rumpel R,  Sobarzo C,  Schreiner D,  Brandes G, Lustig  L, Vazquez-Levin MH, Grothe  C, Marín-Briggiler C.  J Cell Physiology, 2018, doi0.1002/jcp26876.
     
  • Involvement of Fibroblast Growth Factor 2 (FGF2) and its receptors in the regulation of mouse sperm physiology. Lucía Saucedo, Regina Rumpel, Cristian Sobarzo, Dietmar , Schreiner, Gudrun Brandes, Livia Lustig, Mónica Hebe Vazquez-Levin, Claudia Grothe, Clara Marín-Briggiler. Reproduction, Junio 2018, doi:10.1530/REP-18-0133
     
  • Chapter: “StAR”. Cecilia Poderoso; Ana F. Castillo, Pablo G. Mele, Paula Maloberti, Ernesto J. Podestá. Encyclopedia of Signaling Molecules, 2nd Edition. Editor: Sangdun Choi. Editorial: Springer, New York. Plataforma: Meteor. p: 5161-5169 (2018).
     
  • Subcellular distribution of ERK phosphorylation in tyrosine and threonine depends on redox status in murine lung cells”. Helfenberger K, Villalba N, Buchholz B, Boveris A, Poderoso JJ, Gelpi RJ, Poderoso C. (2018) PLoS One. Feb 28;13(2):e0193022. doi: 10.1371/journal.pone.0193022
     
  • Germ cell apoptosis and survival in testicular inflammation. MS Theas. Andrologia, in the “Special issue on inflammation”. En prensa, 2018.
     
  • JAK2/STAT5 pathway mediates prolactin-induced apoptosis of lactotropes, Neuroendocrinology. Nataly de Dios, Santiago Orrillo, Martín Irizarri, Florencia Gottardo, María Susana Theas, Florence Boutillon, Marianela Candolfi, Adriana Seilicovich Vincent Goffin, Daniel Pisera, Jimena Ferraris. En prensa, 2018.
     
  • Juan Turati. Beca otorgada por la International Brain Research Organization (IBRO) para asistir al  11th FENs Forum of Neuroscience (Berlin, Alemania), 2018.
     
  • Pérez Millán MI, Vishnopolska SA, Daly AZ, Bustamante JP, Seilicovich A, Bergadá I, Braslavsky D, Keselman AC, Lemons RM, Mortensen AH, Marti MA, Camper SA, Kitzman JO. Next generation sequencing panel based on single molecule molecular inversion probes for detecting genetic variants in children with hypopituitarism. Mol Genet Genomic Med. 2018 May 8. doi: 10.1002/mgg3.395.

2017

  • PATENTE:
    Registro: US 9737515 B2. Otorgado. Aprobada EEUU 4/2017. "COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OF ACSL4-OVEREXPRESSING TUMORS". Podesta, Ernesto J.; Castillo, Ana F.; Orlando, Ulises; Maloberti, Paula; Solano, Angela. CONICET.
     
  • PATENTE:
    En trámite. PCT INTERNACIONAL, Enviada 3/2017. "COMPOSITIONS AND METHODS FOR INHIBITING TUMOR GROWTH" Podestá, Ernesto J; Maloberti, Paula; Orlando, Ulises; Dattilo, Melina; Castillo, Ana Fernanda; Solano, Angela. CONICET.
     
  • L. Carniglia L, D. Ramírez,  D. Durand, J. Saba, J. Turati, C. Caruso, Scimonelli TN, Lasaga M. Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Disease. Mediators Inflamm 2017:5048616.
     
  • D. Durand, L. Carniglia, J. Turati, D. Ramírez, J. Saba, C. Caruso, M. Lasaga. Amyloid-beta neurotoxicity and clearance are both regulated by glial group II metabotropic glutamate receptors. Neuropharmacology 2017, 123:274-286
     
  • Moreno Ayala MA, Gottardo MF, Gori MS, Nicola Candia AJ, Caruso C, De Laurentiis A, Imsen M, Klein S, Bal de Kier Joffé E, Salamone G, Castro MG, Seilicovich A, Candolfi M. Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer. J Cancer Res Clin Oncol. 2017, 143 (9): 1713-1732.
     
  • Zárate S, Astiz M, Magnani N, Imsen M, Merino F, Alvarez S, Reines A, Seilicovich A. Hormone deprivation alters mitochondrial function and lipid profile in the hippocampus. J Endocrinol. 2017  Apr;23 3(1):1-14. doi: 10.1530/JOE-16-0451. 
     
  • Zárate S, Stevnsner T, Gredilla R. Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair. Front. Aging Neurosci. 9:430, 2017. doi: 10.3389/fnagi.2017.00430.
     
  • Chandran M, Candolfi M, Shah D, Mineharu Y, Yadav VN, Koschmann C, Asad AS, Lowenstein PR, Castro MG. Single vs. combination immunotherapeutic strategies for glioma. Expert Opinion oBiological Therapy 2017 17:543-554.n
     
  • Kamran N, Kadiyala P, Saxena M, Candolfi M, Li Y, Moreno Ayala MA, Raja N, Shah D, Lowenstein PR, Castro MG. Immunosuppressive myeloid cells' blockade in the glioma microenvironment enhances the efficacy of immune stimulatory gene therapy. Molecular Therapy2017 25: 232-248.
     
  • Gottardo MF, Moreno Ayala MA, Zárate S, Ferraris J, Pisera D, Candolfi M, Jaita G, Seilicovich A. Humanin inhibits apoptosis in pituitary tumor cells through several signaling pathways including NF-κB activation Journal Cell Commun Signaling 2017 Dec;11(4):329-340. doi: 10.1007/s12079-017-0388-4. Epub 2017 Apr 4.
     
  • Asad AS, Moreno Ayala MA, Gottardo MF, Zuccato C, Nicola Candia A, Zanetti FA, Seilicovich A, Candolfi M.  Viral gene therapy for breast cancer: Progress and challenges. Expert Opin Biol Ther. 2017 Aug;17(8):945-959. doi: 10.1080/14712598.2017.1338684. Epub 2017 Jun 12.
     
  • Moreno Ayala MA, Gottardo MF, Imsen M, Asad AS, Bal de Kier Joffé E, Casares N, Lasarte JJ, Seilicovich A, Candolfi M. Therapeutic blockade of Foxp3 in experimental breast cancer models. Breast Cancer Res Treat. 2017 Nov;166(2):393-405. doi: 10.1007/s10549-017-4414-2. Epub 2017 Jul 29.
     
  • Moreno Ayala MA, Gottardo MF, Asad AS, Zuccato C, Nicola Candia A, Seilicovich A, Candolfi M. Immunotherapy for the treatment of breast cancer. Expert Opin Biol Ther. 2017 Jul;17(7):797-812. doi: 10.1080/14712598.2017.132456 Epub 2017 May 8. 
     
  • Machado I, Schioth HB, Lasaga M, Scimonelli T, IL-1 beta reduces GluA1 phosphorylation and its surface expression during memory reconsolidation and α-melanocyte-stimulating hormone can modulate these effects.Neuropharmacology. 2018, 128:314-323. doi: 10.1016/j neuropharm.2017.09.041. Epub 2017 Oct 14.
     
  • Suares Alejandra; Mori Sequeiros García María Mercedes; Paz Cristina; Gonzalez-Pardo Verónica. Antiproliferative effects of Bortezomib in endothelial cells transformed by viral G protein-coupled receptor associated to Kaposi's sarcoma. Cellular Signalling; Lugar: Amsterdam; Año: 2017 vol. 32 p. 124 - 132
     
  • Broad-scale recombination pattern in the primitive bird Rhea americana (Ratites, Palaeognathae). del Priore L, Pigozzi MI. PLoS One. 2017 Nov 2;12(11):e0187549. doi: 10.1371/journal.pone.0187549.
     
  • Delia Ramírez. Beca otorgada por la International Brain Research Organization (IBRO) para asistir al XIII European Meeting on Glial Cells in Health and Disease (Edimburgo, Reino Unido), 2017.

2016

  • Kamran N, Calinescu A, Candolfi M, Chandran M, Mineharu Y, Asad AS, Koschmann C, Nunez FJ, Lowenstein PR, Castro MG. Recent advances and future of immunotherapy for glioblastoma. Expert OpinBiolTher. 2016 16:1245-1264.
     
  • Mitochondrial dynamics regulates oxidative metabolism in Leydig tumor cells” Cecilia Poderoso, Cristina Paz, Katia E. Helfenberger and Ernesto J. Podestá. Capítulo 10: General aspects of oxidative stress. “Biochemistry of oxidative stress. Physiopathology and clinical aspects”. Editores: Gelpi RJ, Boveris A, Poderoso JJ. Editorial: Springer, New York. Serie “Advances in Biochemistry in Health and Disease”. ISBN: 978-3-319-45864-9.(2016). http://www.springer.com/la/book/9783319458649.
     
  • Kamran N, Candolfi M, Baker GJ, Moreno Ayala MA, Dzaman M, Lowenstein PR, Castro MG. Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms Fredric P. Manfredsson (ed.), Gene Therapy for Neurological Disorders: Methods and Protocols, Methods in Molecular Biology, vol. 1382 (2016), 467-482 Springer Science+Business Media New York
     
  • Pigozzi MI. The Chromosomes of Birds during Meiosis. Cytogenet Genome Res. 2016; 150(2):128-138. doi: 10.1159/000453541. Review.
     
  • del Priore L, Pigozzi MI. Meiotic recombination analysis in female ducks (Anas platyrhynchos). Genetica. 2016 ; 144(3):307-12. doi: 10.1007/s10709-016-9899-9.
     
  • Magri ML, Gottardo MF, Zárate S, Eijo G, Ferraris MJ, Jaita G, Moreno Ayala MA, Candolfi M, Pisera D, Seilicovich A. Opposite effects of dihydrotestosterone and estradiol on apoptosis in the anterior pituitary gland from male rats. Endocrine 2016 51: 506-516.
     
  • L. Carniglia, D. Ramírez, D. Durand, J. Saba, C. Caruso, M. Lasaga. [Nle4, D-Phe7]-a-MSH inhibits toll-like receptor (TLR)2- and TLR4-induced microglial activation and promotes a M2-like phenotype. PloSone 2016, 11(6):e0158564.
     
  • Paz C, Cornejo Maciel F, Gorostizaga A, Castillo AF, Mori Sequeiros García MM, Maloberti PM, Orlando UD, Mele PG, Poderoso C, Podesta EJ. Role of Protein Phosphorylation and TyrosinePhosphatases in the Adrenal Regulation of Steroid Synthesis and Mitochondrial Function. Front Endocrinol (Lausanne). 2016 Jun 9. Review.
     
  • Gorostizaga AB; Mori Sequeiros García MM; Acquier AB; Lopez-Costa JJ; Mendez CF; Maloberti PM; Paz C. ACTH Modulates PTP-PEST Activity and Promotesits Interaction with Paxillin. Journal of cellular biochemistry; Lugar: New York; Año: 2016 vol. 117 p. 2170 – 2181
     
  • Spectrum of BRCA1/2 variants in 940 patients from Argentina including novel, deleterious and recurrent germline mutations: impact on health care and clinical practice. Angela Rosaria Solano, Florencia Cecilia Cardoso, Vanesa Romano, Florencia Perazzo, Carlos Bas, Gonzalo Recondo, Francisco Bernardo Santillan, Eduardo Gonzalez, Eduardo Abalo, María Viniegra, José Davalos Michel, Lina María Nuñez, Cristina Maria Noblia, Ignacio Mc Lean, Enrique DiazCanton, Reinaldo Daniel Chacon, Gustavo Cortese, Eduardo Beccar Varela, Martín Greco, María Laura Barrientos, Silvia Adela Avila, Hector Daniel Vuotto, Antonio Lorusso, Ernesto Jorge Podesta and Oscar Gaspar Mando. July 2016 doi: 10.18632/oncotarget.10814

2015


2014


2013


2012


Patentes:

  • DESARROLLO DE PRODUCTOS, PROCESOS PRODUCTIVOS Y SISTEMAS TECNOLOGICOS

    Año de referencia: 2017.

    Estado otorgado

    Aprobada en Estados Unidos en Abril del 2017

    Registro: US 9737515 B2

    Denominación del desarrollo: COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OF ACSL4-OVEREXPRESSING TUMORS

    Tipo de desarrollo: Producto

    Breve descripción del desarrollo:

    The present invention relates to compositions and methods for preventing and treating proliferative diseases, such as cancer. More specifically, the present invention relates to compositions and methods for inhibiting tumor growth, particularly breast cancer, in a combined pharmacological treatment. Yet more specifically, the method of the present invention is a method for inhibiting growth of ACSL4-overexpressing tumors. In a preferred embodiment, the invention provides a pharmaceutical composition for inhibiting tumor growth comprising a combination of: i) a first component which is an ACSL4 inhibitor; and ii) a second component selected from a group of chemotherapeutics drugs.

    Áreas de conocimiento: CIENCIAS MÉDICAS Y DE LA SALUD - Medicina Clínica - Oncología

    Autor/es: Podesta, Ernesto J.; Castillo, Ana F.;Orlando, Ulises;Maloberti, Paula;Solano, Angela (INSTITUTO DE INVESTIGACIONES BIOMEDICAS (INBIOMED) ; (CONICET - UBA))

    Inst./es financiadora/s: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET)

    Participación: 100 %

    Año de referencia: 2017

    Envió PCT Internacional

 

  • En trámite 3 de Marzo 2017

    Denominación del desarrollo: COMPOSITIONS AND METHODS FOR INHIBITING TUMIOR GROWTH

    Tipo de desarrollo: Producto

    Breve descripción del desarrollo:

    The present invention relates to compositions and methods for preventing and treating cell proliferation in cancer. More specifically, the present invention relates to compositions and methods for inhibiting tumor growth, and for treating proliferative diseases, particularly colon and breast cancer, with a combined pharmacological approach. Yet more specifically, the compositions for inhibiting tumor growth comprise a combination of: i) a first component which is an ACSL4 inhibitor; and ii) a second component selected from the group consisting of mTOR inhibitor and ER inhibitor.

    Áreas de conocimiento: CIENCIAS MÉDICAS Y DE LA SALUD - Medicina Clínica - Oncología

    Campo aplicación: Salud humana Especialidad: Oncología

    Autor/es: Podestá, Ernesto J; Maloberti, Paula;Orlando, Ulises;Dattilo, Melina;Castillo, Ana Fernanda;Solano, Angela (INSTITUTO DE INVESTIGACIONES BIOMEDICAS (INBIOMED) ; (CONICET - UBA))

    Inst./es financiadora/s: CONSEJO NACIONAL DE INVESTIGACIONES

    CIENTIFICAS Y TECNICAS (CONICET)

    Participación: 100 %